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Changes in pulpal nerves with aging.

K Fried1

  • 1Department of Anatomy, Karolinska Institutet Stockholm, Sweden.

Proceedings of the Finnish Dental Society. Suomen Hammaslaakariseuran Toimituksia
|January 1, 1992
PubMed
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Aging cat dental nerves show structural damage and reduced neuropeptides, impacting pain sensitivity and pulp health. These changes in nerve growth factor receptor expression may contribute to neuropathic pain.

Area of Science:

  • Veterinary Dentistry
  • Neuroscience
  • Gerontology

Background:

  • Aging alters nerve structure and function in various tissues.
  • Dental pulp nerves are crucial for tooth sensation and health.
  • Understanding age-related changes in pulpal nerves is vital for feline oral health.

Purpose of the Study:

  • To investigate age-related ultrastructural changes in cat dental pulp nerves.
  • To examine alterations in neuropeptide expression and nerve growth factor receptor in aging feline pulps.
  • To correlate these neural changes with reduced pulpal sensitivity and potential neuropathic pain.

Main Methods:

  • Electron microscopy to assess nerve fiber degeneration and demyelination.
  • Immunohistochemistry to evaluate calcitonin gene-related peptide, substance P, and nerve growth factor receptor expression.

Related Experiment Videos

  • Analysis of age-related changes in pulpal nerve morphology and neurochemical markers.

    • Main Results:

    • Significant loss and degeneration of unmyelinated and myelinated axons in aged cat pulps.
    • Marked age-related decrease in calcitonin gene-related peptide and substance P immunoreactivity.
    • Reduced nerve growth factor receptor immunoreactivity, with some receptor-positive fibers lacking neuropeptides.

    Conclusions:

    • Aging induces significant ultrastructural and neurochemical changes in cat dental pulp nerves.
    • These alterations correlate with reduced sensory perception and may predispose to neuropathic pain.
    • Senescent changes in pulpal nerves could impact pulp hemoregulation and surrounding tissues.