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Phylogenetic evidence for multiple Alu source genes.

E P Leeflang1, W M Liu, C Hashimoto

  • 1Department of Chemistry, University of California, Davis 95616.

Journal of Molecular Evolution
|July 1, 1992
PubMed
Summary
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A novel Alu element in chimpanzee DNA reveals the PV Alu subfamily is not exclusive to humans. This finding suggests Alu transposition occurred in the chimpanzee lineage after species divergence.

Area of Science:

  • Genomics
  • Molecular Evolution
  • Primate Genetics

Background:

  • Alu elements are repetitive sequences in primate genomes.
  • Previous studies indicated Alu transposition activity across human, gorilla, and chimpanzee lineages.
  • The PV Alu subfamily was previously thought to be human-specific.

Purpose of the Study:

  • To investigate the evolutionary history and distribution of the PV Alu subfamily.
  • To determine if PV Alu elements are present in non-human primate genomes.
  • To understand the implications of Alu transposition for primate phylogeny.

Main Methods:

  • DNA sequence analysis of chimpanzee, human, and gorilla genomes.
  • Identification and characterization of Alu subfamily members.

Related Experiment Videos

  • Phylogenetic analysis to infer transposition events.

    • Main Results:

    • A PV Alu subfamily member was identified in chimpanzee DNA.
    • This specific Alu element is absent in homologous regions of human and gorilla DNA.
    • The presence of PV Alu in chimpanzees indicates transposition after divergence from gorillas and humans.

    Conclusions:

    • The PV Alu subfamily is not exclusive to human DNA.
    • Transposition of PV Alu elements occurred within the chimpanzee lineage.
    • Evidence supports the existence of multiple Alu source genes driving retrotransposition.
    • Acquisition of cis-acting elements via retrotransposition is a potential mechanism.