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Inositol hexakisphosphate receptor identified as the clathrin assembly protein AP-2
S M Voglmaier1, J H Keen, J E Murphy
1Johns Hopkins University School of Medicine, Department of Neuroscience, Baltimore, MD 21205.
Biochemical and Biophysical Research Communications
|August 31, 1992
Abstract:
To clarify the function of the receptor binding protein for inositol hexakisphosphate (IP6), we obtained a partial amino acid sequence from the purified protein and a partial nucleotide sequence from a cDNA clone of the gene. The sequences are essentially identical to those of the alpha-subunit of the clathrin assembly protein AP-2. The IP6 receptor protein analyzed by SDS-PAGE contains a series of subunits which are the same as those of AP-2. Antibodies to AP-2 react with the IP6 receptor protein in immunoblot analysis.