Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hepatic parenchymal perfusion defects detected with CTAP: imaging-pathologic correlation.

M S Peterson1, R L Baron, G D Dodd

  • 1Department of Radiology, University of Pittsburgh Medical Center.

Radiology
|October 1, 1992
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prognostic Factor and Serum Biomarker Changes in Non-Surgical Hepatocellular Carcinoma Patients Treated with Radioembolization.

Japanese journal of gastroenterology and hepatology·2026
Same author

Serum levels of gamma-glutamyl transpeptidase in relation to HCC human biology and prognosis.

Journal of translational science·2021
Same author

Plasma lipids, tumor parameters and survival in HCC patients with HBV and HCV.

Journal of translational science·2021
Same author

Tumor multifocality and serum albumin levels can identify groups of patients with hepatocellular carcinoma and portal vein thrombosis having distinct survival outcomes.

Annals of medicine and surgery (2012)·2021
Same author

Portal Vein Thrombosis and Markers of Inflammation in Hepatocellular Carcinoma.

Journal of gastrointestinal cancer·2020
Same author

Liver Transplantation for a Patient with Hepatocellular Carcinoma with Vascular Invasion and Exceeding Milan Criteria-Happy End Despite it all.

Journal of gastrointestinal cancer·2016

Characteristics of hepatic perfusion defects on computed tomographic arterial portography (CTAP) can help differentiate benign from malignant liver processes. However, some CTAP findings are nonspecific and may require biopsy for definitive diagnosis.

Area of Science:

  • Radiology
  • Hepatology
  • Pathology

Background:

  • Focal hepatic parenchymal perfusion defects are detected using computed tomographic arterial portography (CTAP).
  • Correlation between CTAP findings and underlying pathologic processes is crucial for diagnosis.

Purpose of the Study:

  • To determine if CTAP-detected focal hepatic parenchymal perfusion defect characteristics correlate with underlying pathologic processes.
  • To aid in differentiating benign from malignant liver lesions using imaging features.

Main Methods:

  • Prospective correlation of 245 CTAP-detected perfusion defects in 60 patients with surgical pathology specimens.
  • Characterization of defects by shape, liver location, and relative attenuation value.

Main Results:

Related Experiment Videos

  • Round defects: 58% malignant, 42% benign. Wedge-shaped defects: 2% malignant. Flat defects: 100% benign.
  • Specific locations (anterior to porta hepatis, adjacent to intersegmental fissure) were uniformly benign.
  • Soft-tissue attenuation defects were 56% malignant, while intermediate-attenuation defects were 6% malignant.

Conclusions:

  • CTAP characteristics like shape, location, and attenuation can assist in differentiating benign from malignant hepatic perfusion defects.
  • Nonspecific CTAP findings necessitate further investigation, potentially including biopsy, for accurate diagnosis.