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Published on: April 14, 2011
Case report 749: Primary glomus tumor of bone
T J Simmons1, T J Bassler, C P Schwinn
1Department of Pathology, LAC/USC Medical Center.
Skeletal Radiology
|January 1, 1992
Summary
This case study describes a rare intraosseous glomus tumor in a thumb bone. Immunohistochemistry was crucial for diagnosing this unusual bone tumor.
Area of Science:
- Orthopedic Oncology
- Surgical Pathology
- Diagnostic Histopathology
Background:
- Primary intraosseous glomus tumors are rare, presenting diagnostic challenges.
- Glomus tumors typically arise in the skin and soft tissues.
Observation:
- A 30-year-old man presented with an expanding, lytic lesion in the distal phalanx of his left thumb.
- Histological examination revealed an atypical appearance with myxoid stroma resembling chondroid material.
Findings:
- The tumor's unusual location and microscopic features complicated the diagnosis.
- Immunohistochemical studies showed strong positive staining for muscle-specific actin (MSA) and negative staining for keratin and S-100 protein.
- These findings confirmed the diagnosis of primary intraosseous glomus tumor.
Implications:
- This case highlights the importance of considering rare differential diagnoses in bone lesions.
- Immunohistochemistry is essential for accurate diagnosis of atypical glomus tumors.
- Understanding the histological variations of glomus tumors aids in appropriate patient management.
