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Published on: September 12, 2016
[Indicators of cellular immunity in patients with multiple sclerosis]
Zhurnal Nevropatologii I Psikhiatrii Imeni S.S. Korsakova (Moscow, Russia : 1952)
|January 1, 1992
Summary
This study examined 111 multiple sclerosis patients, finding cellular immunity alterations during exacerbation. Immunocorrective therapy helped stabilize immune function in these patients.
Area of Science:
- Immunology
- Neurology
- Clinical Medicine
Background:
- Multiple sclerosis (MS) is a chronic autoimmune disease affecting the central nervous system.
- Cellular immunity plays a critical role in the pathogenesis of MS.
- Understanding immune system changes during MS exacerbation is crucial for effective treatment.
Purpose of the Study:
- To investigate alterations in cellular immunity in patients with multiple sclerosis during exacerbation.
- To evaluate the impact of immunocorrective therapy on cellular immunity in MS patients.
Main Methods:
- Clinical and functional examinations were performed on 111 MS patients.
- Blood samples were analyzed to assess cellular immunity markers.
- Examinations were conducted twice: upon hospital admission and post-immunocorrective therapy.
Main Results:
- Patients exhibited significant alterations in cellular immunity during MS exacerbation.
- A decline in suppressor cells and an increase in B lymphocytes were observed during exacerbation.
- Immunocorrective therapy resulted in the stabilization of immune function, indicating a positive therapeutic effect.
Conclusions:
- Cellular immunity is significantly altered during multiple sclerosis exacerbations.
- Immunocorrective therapy demonstrates potential in stabilizing immune dysregulation in MS.
- Further research into targeted immunotherapies for MS is warranted.
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