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Related Experiment Videos

Spurious elevation of follicle-stimulating hormone.

D J Cahill1, R Fox, P H Thomas

  • 1University of Bristol Department of Obstetrics and Gynaecology, St Michael's Hospital, United Kingdom.

Acta Obstetricia Et Gynecologica Scandinavica
|July 1, 1992
PubMed
Summary

Follicle-stimulating hormone (FSH) testing in infertile women can yield misleading postmenopausal levels due to assay interference. An alternative assay confirmed normal FSH levels, highlighting the importance of method validation.

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Area of Science:

  • Reproductive Endocrinology
  • Clinical Chemistry
  • Infertility Diagnostics

Background:

  • Primary infertility evaluation in eumenorrheic women.
  • Follicle-stimulating hormone (FSH) as a key biomarker.
  • Potential for assay interference in hormone testing.

Observation:

  • A 33-year-old woman presented with primary infertility.
  • Initial serum FSH measurements indicated postmenopausal levels.
  • An alternative assay revealed normal FSH concentrations.

Findings:

  • Discrepancy in FSH levels between two different assays.
  • Identification of a potential cause for the misleading FSH result.
  • Importance of assay methodology in diagnostic accuracy.

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Implications:

  • Need for careful interpretation of FSH results in infertility.
  • Consideration of alternative assays when results are discordant.
  • Impact of assay variability on clinical decision-making in reproductive medicine.