[Second generation sulfonylurea preparations in the therapy of diabetes mellitus]

The authors present the results of treatment of the patients with diabetes mellitus with hypoglycaemic preparations (sulphonylurea preparations of the second generation): glibenclamide, glibornuride and glydiazinamide. The following preparations were used: glibenclamide of Soviet make, maninil, daonyl, euglucon-5, euglucon, glutryl, glydiazinamide, glipizid. The treatment was carried out in 298 patients. The hypoglycaemic action of the active substances contained in one tablet of each of the preparation was approximately the same. Preparations of the second generation proved to be highly effective without any side-effects which required suspension of the treatment. The best results were obtained in complex therapy with the preparations of the second generation and with biguanides of prolonged action.