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Related Experiment Videos

Alpha 2 adrenergic receptor subtypes in depression: a candidate gene study.

Z Wang1, R R Crowe, V L Tanna

  • 1Department of Psychiatry, University of Iowa College of Medicine, Iowa City 52242.

Journal of Affective Disorders
|July 1, 1992
PubMed
Summary

This study investigated alpha 2 adrenergic receptor genes in unipolar depression. The findings indicate these specific genes are not linked to depression in the studied families, suggesting other genetic factors may be involved.

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Genetics

Background:

  • Alpha 2 adrenergic receptors regulate norepinephrine release in the locus ceruleus.
  • Presynaptic alpha 2 autoreceptors are implicated in depression pathogenesis and symptoms.

Purpose of the Study:

  • To investigate the role of two brain-expressed alpha 2 adrenergic receptor genes in unipolar depression.
  • To perform linkage analyses in multiplex pedigrees to identify potential genetic markers for depression.

Main Methods:

  • Linkage analysis was conducted on 17 multiplex pedigrees with unipolar depression.
  • Two specific alpha 2 adrenergic receptor genes were selected as genetic markers.

Main Results:

  • Neither of the two alpha 2 adrenergic receptor genes showed support for linkage to depression.

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  • Lod scores below -2 were observed in both familial pure depressive disease and depression spectrum disease pedigrees.

    • Conclusions:

    • The studied alpha 2 adrenergic receptor genes are not associated with depression in the analyzed pedigrees.
    • Depression in these families is unlikely to be caused by mutations in the investigated alpha 2 adrenergic receptor genes.