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[Platelet receptors: nomenclature--structure--function. 1].

J H Beer1

  • 1Medizinische Universitätsklinik, Inselspital, Bern.

Schweizerische Medizinische Wochenschrift
|August 22, 1992
PubMed
Summary
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This review summarizes platelet receptors, their structure, function, and roles in thrombosis, hemostasis, and cell adhesion. It details various receptor types, including integrins and those exclusive to platelets, and their interactions with agonists and coagulation factors.

Area of Science:

  • Hematology
  • Molecular Biology
  • Cell Biology

Context:

  • Platelets play crucial roles in hemostasis and thrombosis.
  • Understanding platelet receptors is key to comprehending these processes.
  • Platelet receptors are diverse, belonging to families like cell-adhesion molecules.

Purpose:

  • To provide a comprehensive summary of current knowledge on platelet receptors.
  • To discuss the structure, function, and ligand interactions of these receptors.
  • To review the involvement of platelet receptors in thrombosis, hemostasis, cell adhesion, and invasion.

Summary:

  • The review covers platelet receptor nomenclature, structure, and function.
  • It details the roles of various receptors, including integrins and platelet-specific receptors like GP IIb/IIIa.

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  • Interactions with platelet agonists and binding sites for coagulation/fibrinolysis factors are also discussed.

    • Impact:

    • This knowledge is vital for developing targeted therapies for thrombotic disorders.
    • Understanding receptor function aids in designing anti-platelet drugs.
    • Insights into receptor interactions can inform strategies for managing bleeding disorders.