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[Skin cancer and virus].

M Niimura1

  • 1Department of Dermatology, Jikei University School of Medicine, Tokyo, Japan.

Human Cell
|June 1, 1992
PubMed
Summary

Certain human papillomaviruses (HPV) are linked to benign warts, while others are associated with skin cancers. Malignant HPV types contain DNA that transforms human cells, with activity mapped to the E6 and E7 genes.

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Area of Science:

  • Virology
  • Oncology
  • Dermatology

Context:

  • Human papillomaviruses (HPV) are commonly linked to benign skin and anogenital warts.
  • However, the presence of HPV-DNA in certain skin cancers suggests a potential oncogenic role for specific HPV types.
  • This association is particularly noted in penile cancers, vulval cancers, and anogenital Bowen's disease.

Purpose:

  • To explore the association between different types of human papillomaviruses (HPV) and both benign and malignant lesions.
  • To investigate the potential role of HPV in malignant transformation, particularly in rare conditions like epidermodysplasia verruciformis.
  • To understand the molecular mechanisms underlying HPV-induced cellular transformation.

Summary:

  • Over 60 HPV types have been identified, categorized into benign and malignant groups based on their clinical manifestations and natural outcomes.
  • Malignant HPV types have demonstrated the ability to transform human keratinocytes in vitro.
  • The transforming activity of oncogenic HPV types has been localized to the viral E6 and E7 genes.

Impact:

  • This research highlights the dual nature of HPV, differentiating between oncogenic and non-oncogenic strains.
  • Understanding the specific HPV types and their associated genes (E6/E7) is crucial for developing targeted prevention and treatment strategies for HPV-related cancers.
  • The findings contribute to the broader understanding of viral carcinogenesis and the molecular basis of skin malignancies.

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