[Pathogenetic mechanisms in neonatal infections]

Area of Science:

• Neonatology
• Infectious Diseases
• Embryology and Fetal Development

Context:

• Neonatal infections pose significant risks to newborns.
• Understanding infection pathways is crucial for timely diagnosis and treatment.
• Prenatal, intrapartum, and postnatal infection routes require distinct management strategies.

Purpose:

• To review the pathogenetic mechanisms of neonatal infections.
• To discuss the impact of antenatal infections on embryo and fetus.
• To correlate pathogenetic mechanisms with clinical and paraclinical findings for diagnosing common newborn infections.

Summary:

• The review examines the origins and development of infections in newborns, covering prenatal, intrapartum, and postnatal periods.
• It details the effects of infections on embryonic and fetal development.
• Emphasis is placed on linking disease mechanisms to clinical presentations and diagnostic markers for frequent neonatal infections.

Impact:

• Provides a comprehensive overview of neonatal infection pathogenesis.
• Aids in the clinical diagnosis of common newborn infections by correlating mechanisms with symptoms.
• Informs strategies for preventing and managing infections in neonates.