Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The placenta, PGE2 and parturition.

G D Thorburn1

  • 1Department of Physiology, Monash University, Clayton, Victoria, Australia.

Early Human Development
|June 1, 1992
PubMed
Summary
This summary is machine-generated.

The fetal placenta secretes prostaglandin E2 (PGE2), a hormone that regulates fetal organ function and development. Its removal at birth allows newborns to adapt to extrauterine life with mature organ systems.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pulsatile output of prostaglandin F(2alpha) does not increase around the time of luteolysis in the pregnant goat.

Biology of reproduction·1999
Same author

Effects of prostaglandin E2 on renal function and lung liquid dynamics in foetal sheep.

Clinical and experimental pharmacology & physiology·1998
Same author

Studies on the role of ACTH in the regulation of adrenal responsiveness and the timing of parturition in the ovine fetus.

The Journal of endocrinology·1998
Same author

Angiotensin II infusion in vivo does not modulate cortisol secretion in the late-gestation ovine fetus.

The American journal of physiology·1998
Same author

Fetal and maternal endocrine changes approaching parturition in the goat: lack of evidence for prostaglandins E2 and F2alpha as signals for luteolysis.

Biology of reproduction·1998
Same author

Effect of alteration of maternal plasma progesterone concentrations on fetal behavioural state during late gestation.

The Journal of endocrinology·1997

Area of Science:

  • Reproductive biology
  • Developmental physiology
  • Endocrinology

Background:

  • Prostaglandin E2 (PGE2) is secreted by the ovine fetal placenta.
  • PGE2 acts as a circulating regulator of fetal organ physiology, analogous to adult catecholamines.
  • PGE2's actions are mediated by three receptor subtypes, influencing intracellular calcium and cAMP levels.

Purpose of the Study:

  • To explore the role of placental PGE2 in regulating fetal organ function and development.
  • To investigate PGE2's involvement in fetal breathing, ductus arteriosus patency, and thermogenesis.
  • To examine PGE2's influence on fetal metabolism, insulin secretion, and the hypothalamo-pituitary-adrenal axis.

Main Methods:

  • This study is primarily a review and discussion of existing research and proposed mechanisms.

Related Experiment Videos

  • It synthesizes findings on PGE2's effects on various fetal systems.
  • It discusses the potential role of PGE2 in initiating labor.

    • Main Results:

    • Placental PGE2 suppresses fetal organ function, allowing for maturation during development.
    • PGE2 maintains ductus arteriosus patency, suppresses non-shivering thermogenesis, stimulates insulin secretion, and inhibits hepatic gluconeogenesis.
    • PGE2 activates the fetal hypothalamo-pituitary-adrenal axis.

    Conclusions:

    • Placental PGE2 plays a critical role in fetal adaptation and development.
    • The removal of PGE2 at birth is crucial for the newborn's transition to extrauterine life.
    • PGE2 may be involved in the initiation of parturition in sheep.