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Effects of inhaled alpha-emitting actinides on mouse alveolar macrophages
1Biomedical Research Department, AEA Environment and Energy, Harwell Laboratory, Oxfordshire, UK.
Environmental Health Perspectives
|July 1, 1992
Abstract:
The effects of inhaled alpha-emitting actinides on the alveolar macrophage (AM) population of the rodent lung are reviewed and, in particular, of the effects of 239PuO2 on murine AM. The effects discussed include changes the AM pool size, macrophage diameter, mobility, phagocytic competence, and enzyme content. Finally, similarities in the dose-response relationships for the induction of nuclear aberrations by alpha emitters and in the induction of lung tumors by the same materials are noted.