Related Experiment Videos
Rabbit isolated vas deferens possess A1 and A2 adenosine receptors
1Department of Pharmacology, Faculty of Medicine, Tehran University of Medical Sciences, Iran.
Abstract:
1. The effects of adenosine, 5'-N-ethylcarboxamidoadenosine (NECA), 2-chloroadenosine, N6-phenylisopropyladenosine (L-PIA and D-PIA) and N6-cyclohexyladenosine (CHA) were examined on the rabbit isolated vas deferens. 2. All the analogues in a concentration-dependent manner inhibited contractile response to electrical stimulation. 3. 8-Phenyltheophylline caused a rightward shift of all the adenosine and its analogues' concentration-response curves. 4. The order of potency for the adenosine and its analogues on the rabbit isolated vas deferens was: CHA = NECA greater than L-PIA greater than 2-chloroadenosine greater than D-PIA greater than adenosine. 5. It is concluded that CHA, NECA, L-PIA, 2-chloroadenosine, D-PIA and adenosine mediate their inhibitory effects on the rabbit isolated muscle via both A1 and A2 adenosine receptors.