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Related Experiment Videos

Aqueous humor messengers in the transient decrease of intraocular pressure after ganglionectomy.

J H Liu1

  • 1Department of Ophthalmology, University of California, San Diego, La Jolla 92093-0946.

Investigative Ophthalmology & Visual Science
|October 1, 1992
PubMed
Summary
This summary is machine-generated.

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Superior cervical ganglionectomy in rabbits caused a significant decrease in intraocular pressure (IOP). Norepinephrine in aqueous humor did not increase, but cyclic adenosine monophosphate (cAMP) levels did, suggesting cAMP-mediated pathways influence IOP.

Area of Science:

  • Ophthalmology
  • Neuroscience
  • Pharmacology

Background:

  • Superior cervical ganglionectomy (SCG) in rabbits leads to a decrease in intraocular pressure (IOP).
  • Previous hypotheses suggested norepinephrine (NE) accumulation in aqueous humor contributes to this IOP reduction.
  • Direct measurement of aqueous humor NE has been technically challenging.

Purpose of the Study:

  • To investigate the role of norepinephrine (NE) and cyclic adenosine monophosphate (cAMP) in the transient intraocular pressure (IOP) decrease following superior cervical ganglionectomy (SCG).
  • To quantify aqueous humor NE and cAMP concentrations after SCG in rabbits.

Main Methods:

  • Unilateral SCG was performed on twelve New Zealand albino rabbits.
  • Intraocular pressure (IOP) was measured 22 hours post-surgery.

Related Experiment Videos

  • Aqueous humor NE and cAMP concentrations were extracted and quantified using high-performance liquid chromatography-electrochemical detection.

    • Main Results:

    • A significant IOP decrease was observed in the operated eyes compared to the contralateral eyes (16.1 vs. 20.9 mmHg).
    • Aqueous humor NE concentrations were not significantly different between the operated and contralateral eyes.
    • Aqueous humor cAMP concentrations were significantly higher in the operated eyes compared to the contralateral eyes (29.8 vs. 11.7 pmol/ml).

    Conclusions:

    • Norepinephrine (NE) in the aqueous humor does not appear to be the direct cause of the transient IOP decrease after superior cervical ganglionectomy (SCG).
    • Elevated cyclic adenosine monophosphate (cAMP) levels in the aqueous humor suggest that cAMP-mediated ocular activities may play a role in the IOP changes following SCG.