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Does hormonal therapy have any benefit for bleeding angiodysplasia?
B S Lewis1, P Salomon, S Rivera-MacMurray
1Division of Gastroenterology, Mount Sinai Medical Center, New York, New York.
Journal of Clinical Gastroenterology
|September 1, 1992
Summary
Hormonal therapy showed no significant benefit in reducing intestinal bleeding caused by small bowel angiodysplasia. This study found no difference in transfusion needs between treated and untreated patients.
Area of Science:
- Gastroenterology
- Hepatology
- Internal Medicine
Background:
- Small bowel angiodysplasia is a common cause of gastrointestinal bleeding.
- Hormonal therapy has been proposed as a treatment option for this condition.
Purpose of the Study:
- To evaluate the efficacy of daily hormonal therapy in diminishing intestinal bleeding from small bowel angiodysplasia.
Main Methods:
- A cohort study involving 64 patients with small bowel angiodysplasia.
- Thirty patients received hormonal therapy (norethynodrel with mestranol or conjugated estrogens).
- Thirty-four patients served as a control group, either refusing therapy or diagnosed before its resurgence.
Main Results:
- No significant difference in transfusion requirements was observed between the treated and untreated groups.
- Fifty percent of the treated group and 44% of the untreated group required no further transfusions.
- Mean monthly transfusion requirements for packed red blood cells did not differ significantly before or during therapy, nor compared to the control group.
Conclusions:
- The study findings do not support the use of hormonal therapy for managing bleeding associated with small intestinal angiodysplasia.
- Further research may be needed to explore alternative or adjunctive treatments.