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Combination treatment with ribavirin and interferon for coxsackievirus B3 replication
I Okada1, A Matsumori, Y Matoba
1Department of Internal Medicine, Faculty of Medicine, Kyoto University, Japan.
Abstract:
The effects of combined treatment with ribavirin and recombinant human leukocyte interferon-alpha A/D against Coxsackievirus B3 replication were investigated in cultured cells. Recombinant human leukocyte interferon-alpha A/D was applied 12 hours before Coxsackievirus B3 inoculation and ribavirin was applied 1 hour after Coxsackievirus B3 inoculation on FL (human amnion) cell monolayers. These drugs inhibited Coxsackievirus B3 replication synergistically by plaque-reduction assay. This method of applying drugs may be useful in preventing and treating Coxsackie B virus infection.
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