Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Stereotactic brain biopsy in AIDS.

C Zimmer1, S Märzheuser, S Patt

  • 1Institut für Neuropathologie, Klinikum Steglitz, Freie Universität, Berlin, Federal Republic of Germany.

Journal of Neurology
|August 1, 1992
PubMed
Summary

Stereotactic brain biopsy is effective for diagnosing brain lesions in patients with HIV/AIDS, achieving a 92% diagnosis rate. Early diagnosis, especially for primary CNS lymphoma, is crucial for effective treatment.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

FKBP5 expression is related to risky foraging in house sparrows.

Hormones and behavior·2026
Same author

Divergent climate impacts despite similar response to temperature in a widespread aerial insectivore.

bioRxiv : the preprint server for biology·2025
Same author

Differentially spliced mitochondrial CYP419A1 contributes to ethiprole resistance in Nilaparvata lugens.

Insect biochemistry and molecular biology·2025
Same author

Screening H3 Histone Acetylation in a Wild Bird, the House Sparrow (<i>Passer Domesticus</i>).

Integrative organismal biology (Oxford, England)·2024
Same author

Thoracic impedance pneumography in propofol-sedated patients undergoing percutaneous endoscopic gastrostomy (PEG) placement in gastrointestinal endoscopy: A prospective, randomized trial.

Journal of clinical anesthesia·2024
Same author

Reconstruction of the Corticospinal Tract in Patients with Motor-Eloquent High-Grade Gliomas Using Multilevel Fiber Tractography Combined with Functional Motor Cortex Mapping.

AJNR. American journal of neuroradiology·2023

Area of Science:

  • Neurology
  • Infectious Diseases
  • Oncology

Background:

  • Brain lesions are common in HIV-seropositive patients, necessitating rapid diagnosis for treatable conditions.
  • Stereotactic brain biopsy is a potential diagnostic tool in this population.

Purpose of the Study:

  • To evaluate the efficacy of stereotactic brain biopsy in diagnosing brain lesions in patients with Acquired Immunodeficiency Syndrome (AIDS).

Main Methods:

  • Retrospective study of 25 HIV-infected patients undergoing stereotactic brain biopsy.
  • Lesion identification using MRI and/or CT scans.
  • Biopsy samples analyzed via cytology, histology, electron microscopy, immunohistochemistry, animal tests, and PCR.

Main Results:

Related Experiment Videos

  • A definite diagnosis was achieved in 92% of cases.
  • Diagnoses included primary CNS lymphoma (PCNSL), toxoplasmosis, progressive multifocal leukoencephalopathy (PML), and co-infections.
  • Immunohistochemistry and PCR were vital for diagnosing toxoplasmosis and PML.

    • Conclusions:

    • Stereotactic brain biopsy is an effective method for diagnosing HIV-associated brain lesions.
    • Early and accurate histological diagnosis is mandatory for optimal treatment, particularly for radiosensitive PCNSLs.