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Characterization of a new tissue-specific transcription factor binding to the simian virus 40 enhancer TC-II
A L Lattion1, E Espel, P Reichenbach
1Swiss Institute for Experimental Cancer Research, Epalinges.
Molecular and Cellular Biology
|November 1, 1992
Abstract:
We have biochemically and functionally characterized a new transcription factor, NP-TCII, which is present in nuclei from unstimulated T and B lymphocytes but is not found in nonhematopoietic cells. This factor has a DNA-binding specificity similar to that of NF-kappa B but is unrelated to this or other Rel proteins by functional and biochemical criteria. It can also be distinguished from other previously described lymphocyte-specific DNA-binding proteins.