Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Chest pain due to sumatriptan].

B H Stricker1, J P Ottervanger

  • 1Bureau Bijwerkingen Geneesmiddelen, Rijswijk.

Nederlands Tijdschrift Voor Geneeskunde
|September 5, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Are higher antidepressant plasma concentrations associated with fall risk in older antidepressant users?

European geriatric medicine·2023
Same author

Final benefit of primary percutaneous coronary intervention for ST-elevation myocardial infarction in older patients: long-term results of a randomised trial.

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·2022
Same author

Resting heart rate and incident atrial fibrillation: A stratified Mendelian randomization in the AFGen consortium.

PloS one·2022
Same author

Candidate genetic variants and antidepressant-related fall risk in middle-aged and older adults.

PloS one·2022
Same author

Appendectomy and the subsequent risk of cancer: A prospective population-based cohort study with long follow-up.

Cancer epidemiology·2022
Same author

Semi-quantitative assessment of ischemia with rubidium-82 PET myocardial perfusion imaging.

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology·2021
Same journal

[Insulin intoxications caused by falsified semaglutide].

Nederlands tijdschrift voor geneeskunde·2026
Same journal

[Professional skepticism in medical research].

Nederlands tijdschrift voor geneeskunde·2026
Same journal

[Improving mobility in painful osteoarthritis].

Nederlands tijdschrift voor geneeskunde·2026
Same journal

[The effectiveness and costs of the Back At work After Surgery (BAAS) work-integrated care pathway on return to work for patients receiving knee arthroplasty].

Nederlands tijdschrift voor geneeskunde·2026
Same journal

[The rise of genetic therapies: urgent moral and societal questions].

Nederlands tijdschrift voor geneeskunde·2026
Same journal

[A man with a wound on his elbow].

Nederlands tijdschrift voor geneeskunde·2026
See all related articles

Sumatriptan, a migraine drug, can cause chest pain in some users, even those without heart disease. Doctors advise caution and contraindicate its use in patients with existing coronary artery conditions.

Area of Science:

  • Pharmacology
  • Cardiology
  • Clinical Toxicology

Context:

  • Sumatriptan (Imigran) has been available since May 1991.
  • Adverse drug reaction reports are monitored by the Netherlands Centre for Monitoring of Adverse Reactions to Drugs.
  • 13 reports of chest symptoms linked to sumatriptan use were received.

Purpose:

  • To document and analyze adverse events of substernal chest tightness or pain associated with sumatriptan use.
  • To assess the safety profile of sumatriptan concerning cardiovascular side effects.

Summary:

  • 13 patients (11 female, 2 male, average age 41) reported angina-like symptoms, primarily substernal chest tightness or pain.
  • Symptoms typically occurred within one hour of oral or subcutaneous sumatriptan administration.

Related Experiment Videos

  • Cardiovascular assessments (ECG, echocardiography) were normal after symptom resolution, and most patients had no prior history of such symptoms.

    • Impact:

    • Highlights the potential cardiovascular risks of sumatriptan, including angina-like symptoms.
    • Reinforces the contraindication of sumatriptan in patients with coronary artery disease or variant angina pectoris.
    • Advises cautious use of sumatriptan in the general migraine patient population.