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Origin of brain 2',3'-cyclic-nucleotide 3'-phosphodiesterase doublet
T Kurihara1, Y Tohyama, J Yamamoto
1Institute of Life Science, Soka University, Tokyo, Japan.
Neuroscience Letters
|April 13, 1992
Abstract:
The present study established that 2',3'-cyclic-nucleotide 3'-phosphodiesterase doublet common to mammalian brain originates from an alternative splicing. Peptides specific to the predicted larger translation product were synthesized and antisera against these peptides were prepared. Immunostaining of SDS/PAGE blots showed that the antisera react with the larger protein, but not with the smaller protein, of 2',3'-cyclic-nucleotide 3'-phosphodiesterase doublet in all mammals studied.