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Immobilization of human thrombomodulin on glass beads and its anticoagulant activity
M Akashi1, I Maruyama, N Fukudome
1Department of Applied Chemistry and Chemical Engineering, Faculty of Engineering, Kagoshima University, Japan.
Bioconjugate Chemistry
|September 1, 1992
Abstract:
Human thrombomodulin (TM) was for the first time immobilized on glass beads by the reaction between the carboxyl group of TM and the amino group of glass beads using water-soluble carbodiimide. Immobilized human TM exhibited both anticoagulant activity and inhibition of platelet aggregation of human blood.