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Determination of mitoxantrone by flow injection analysis using an amperometric detector
J C Cortina Villar1, A Costa García, P Tuñón Blanco
1Department of Physical and Analytical Chemistry, University of Oviedo, Principality of Asturias, Spain.
Journal of Pharmaceutical and Biomedical Analysis
|April 1, 1992
Summary
A new flow injection analysis method accurately determines mitoxantrone using a carbon paste electrode. This fast and reproducible technique is suitable for analyzing pharmaceutical preparations.
Area of Science:
- Analytical Chemistry
- Electrochemistry
- Pharmaceutical Analysis
Background:
- Accurate quantification of mitoxantrone is crucial for pharmaceutical quality control.
- Existing analytical methods may lack speed or reproducibility for routine analysis.
Purpose of the Study:
- To develop a novel flow injection analysis (FIA) method for mitoxantrone determination.
- To validate the FIA method using a laboratory-modified flow cell with a carbon paste electrode (CPE).
Main Methods:
- Flow injection analysis with a CPE amperometric detector.
- Sample injection into a 0.1 M perchloric acid carrier stream (pH 1.12).
- Mitoxantrone oxidation at +0.90 V, utilizing a 60-cm delay coil and canal thin-layer detector at 4 mL/min flow rate.
Main Results:
- The FIA method demonstrated effective determination of mitoxantrone within the concentration range of 5 x 10(-8) to 1 x 10(-5) M.
- The developed system was successfully applied to quantify mitoxantrone in a pharmaceutical preparation.
- The method exhibited high speed and reproducibility.
Conclusions:
- The developed FIA method offers a fast, reproducible, and effective approach for mitoxantrone analysis.
- This technique is well-suited for the quality control of pharmaceutical formulations containing mitoxantrone.