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Hyperactive T-cell function in young NZB mice; increased proliferative responses to allogenic cells

D W Palmer, M J Dauphinée, E Murphy

    Clinical and Experimental Immunology
    |March 1, 1976
    PubMed

    The one-way mixed lymphocyte reaction was employed to study proliferative responses to antigens by mature, immunocompetent T cells from NZB mice 3 weeks to 4 months old. Compared to cells from control mice of the same H-2 type, thymus, spleen and lymph node cells from NZB mice were hyperactive in this response. The results are discussed in relation to possible effects of chronic stimulation by endogenous type C leukaemia virus upon differentiation of functional T cells or upon regulation by T cells of other T-cell functions, including augmentation of antibody responses.

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