Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Conversion relations for quantitative CT bone mineral densities measured with solid and liquid calibration standards.

M M Goodsitt1

  • 1Department of Radiology, University of Washington, Seattle.

Bone and Mineral
|November 1, 1992
PubMed
Summary

New solid calibration standards for bone mineral density (BMD) measurements using quantitative CT (QCT) are effective. Conversion relations derived are independent of body size and marrow composition, depending primarily on X-ray tube voltage.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Assessment of calibration methods for estimating bone mineral densities in trauma patients with quantitative CT: an anthropomorphic phantom study.

Academic radiology·2001
Same author

Computerized image analysis: estimation of breast density on mammograms.

Medical physics·2001
Same author

Digital mammography: observer performance study of the effects of pixel size on the characterization of malignant and benign microcalcifications.

Academic radiology·2001
Same author

Stereomammography: evaluation of depth perception using a virtual 3D cursor.

Medical physics·2000
Same author

Design and evaluation of an external filter technique for exposure equalization in mammography.

Medical physics·1999
Same author

Design of a high-sensitivity classifier based on a genetic algorithm: application to computer-aided diagnosis.

Physics in medicine and biology·1998

Area of Science:

  • Medical Physics
  • Radiology
  • Biomedical Engineering

Background:

  • Quantitative CT (QCT) bone mineral density (BMD) measurements traditionally use K2HPO4 in liquid standards.
  • Recently introduced hydroxyapatite in water-equivalent plastic (solid) standards offer greater stability.
  • Deriving conversion relations is crucial for integrating these new solid standards into existing QCT protocols.

Purpose of the Study:

  • To investigate the dependence of conversion relations between liquid and solid QCT calibration standards.
  • To assess the influence of X-ray tube voltage, marrow composition, and patient body size on these relations.
  • To establish reliable methods for utilizing stable solid standards in BMD assessment.

Main Methods:

  • Utilized five diverse composition vertebral marrow inserts and a Humanoid phantom with an L1 vertebra.

Related Experiment Videos

  • Acquired QCT data using a GE 9800 scanner at 80 kVp and 140 kVp (single-energy) and dual-energy modes.
  • Manufactured calibration standards from Image Analysis using hydroxyapatite (solid) and K2HPO4 (liquid) references.

    • Main Results:

    • Achieved high correlation (r > 0.999) and low SEE (< 2 mg/ml) between liquid and solid referenced BMD measurements.
    • Conversion slopes were consistent across different body sizes, indicating independence from this factor.
    • Conversion relations demonstrated dependence on X-ray tube voltage (kVp) but were largely independent of marrow composition.

    Conclusions:

    • Established reliable conversion relations for using stable hydroxyapatite solid standards in QCT BMD measurements.
    • Conversion accuracy is primarily dependent on X-ray tube voltage (kVp), not patient size or marrow type.
    • While solid standards offer stability, potential issues requiring further discussion exist.