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Updated: Aug 17, 2026

Nerve Excitability Assessment in Chemotherapy-induced Neurotoxicity
Published on: April 26, 2012
Inflammatory peripheral neuropathy following high dose chemotherapy and autologous bone marrow transplantation
R M Bashir1, P Bierman, R McComb
1Department of Internal Medicine, University of Nebraska Medical Center, Omaha.
Abstract:
A 40-year-old man with non-Hodgkin's lymphoma developed severe ascending sensorimotor neuropathy 10 days after treatment with high dose chemotherapy and autologous bone marrow rescue. The neuropathy had axonal plus demyelinating features on electrophysiological studies. Sural nerve biopsy showed heavy infiltration of the epineurium and endoneurium with mononuclear cells. The patient had no other evidence of graft-versus-host disease. He failed to respond to plasmapheresis but responded to high dose steroids.
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