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Anti-hepatitis C virus in the elderly: a seroepidemiological study in a home for the aged
A Floreani1, T Bertin, G Soffiati
1Department of Gastroenterology, University of Padova, Italy.
Insights
This study surveyed elderly individuals in institutions for hepatitis C virus (HCV) and hepatitis B virus (HBV) infections. Prevalence of anti-HCV was 2.2%, similar to blood donors, suggesting acquired infections in these settings.
Area of Science:
- Hepatology
- Infectious Diseases
- Geriatric Medicine
Background:
- Hepatitis C virus (HCV) and Hepatitis B virus (HBV) are significant global health concerns.
- Understanding the seroprevalence of these viruses in institutionalized elderly populations is crucial for public health strategies.
Purpose of the Study:
- To determine the seroprevalence of anti-HCV and HBV markers in institutionalized elderly individuals.
- To investigate clinical details and co-infections in anti-HCV positive subjects.
Main Methods:
- A seroepidemiological survey was conducted on 315 institutionalized elderly people.
- Testing included anti-HCV antibodies and HBV serum markers (e.g., HBsAg).
- Clinical data and serum transaminase levels were analyzed for positive subjects.
Main Results:
- The prevalence of anti-HCV was 2.2%, and HBV markers were found in 36.8% (HBsAg in 0.6%).
- One subject showed co-infection with anti-HCV and HBsAg.
- Serum transaminase levels were normal in all subjects except the co-infected individual.
Conclusions:
- The prevalence of anti-HCV in institutionalized elderly is comparable to that of blood donors in the same region.
- Geriatric institutions may house individuals with previously acquired HCV and HBV infections.
- Further research into infection control and management within these settings is warranted.
Abstract:
A seroepidemiological survey of anti-hepatitis C virus (anti-HCV) was carried out in 315 institutionalized elderly people. HBV serum markers were tested in the same sera. Clinical details were also studied in the anti-HCV-positive subjects. The overall prevalence of anti-HCV was 2.2%, while the prevalence of HBV serum markers was 36.8% (the HBsAg prevalence was 0.6%). In 1 subject anti-HCV was found in association with HBsAg positivity. Serum transaminase levels were found within the normal range in all 315 subjects (either anti-HCV+ve and anti-HCV-ve), except in the subject who was found to be HBsAg-positive and anti-HCV+ve. In conclusion we found in the institutionalized elderly people a similar prevalence of anti-HCV compared to blood donors of the same geographical area; homes for the aged appear to bring together subjects with previously acquired infections.