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Related Experiment Videos

Human studies with the chelating agents, DMPS and DMSA.

H V Aposhian1, R M Maiorino, M Rivera

  • 1University Department of Molecular and Cellular Biology, University of Arizona, Tucson 85721.

Journal of Toxicology. Clinical Toxicology
|January 1, 1992
PubMed
Summary

Meso-2,3-dimercaptosuccinic acid (DMSA) and 2,3-dimercaptopropane-1-sulfonic acid (DMPS) show potential in mercury excretion. DMPS effectively increased urinary mercury in individuals with dental amalgams.

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Area of Science:

  • Pharmacology
  • Toxicology
  • Biochemistry

Background:

  • Meso-2,3-dimercaptosuccinic acid (DMSA) binds to plasma albumin and is excreted as a DMSA-cysteine mixed disulfide.
  • Dental amalgams are a potential source of mercury exposure in humans.
  • DMSA analogs are being developed to enhance cellular uptake of chelating agents.

Purpose of the Study:

  • To determine the pharmacokinetics of DMSA in humans.
  • To investigate the effect of dental amalgams on mercury body burden.
  • To evaluate the efficacy of 2,3-dimercaptopropane-1-sulfonic acid (DMPS) in increasing mercury excretion.

Main Methods:

  • Pharmacokinetic analysis of DMSA after oral administration in humans.
  • Measurement of urinary mercury excretion in volunteers after DMPS administration.

Related Experiment Videos

  • Correlation analysis between amalgam score and mercury excretion.

    • Main Results:

    • DMSA pharmacokinetic parameters (tmax, t1/2, Cmax) were determined in humans.
    • Oral administration of 300 mg DMPS increased mean urinary mercury excretion over 9 hours.
    • A positive correlation was observed between dental amalgam load and mercury excretion following DMPS treatment.

    Conclusions:

    • DMPS may be valuable for enhancing mercury excretion and improving the reliability of mercury exposure assessment.
    • DMSA analogs show promise in increasing biliary excretion of heavy metals like platinum and cadmium in animal models.