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[H(+)-ATPase and H(+), K(+)-ATPase].

N Takeguchi1

  • 1Department of Pharmaceutical Physiology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|September 1, 1992
PubMed
Summary

This study summarizes vacuole-type (V-type) and P-type proton transporting ATPases involved in epithelial ion transport. These ATPases are crucial for cellular functions including organelle acidification and secretion in the stomach and kidney.

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Area of Science:

  • Biochemistry and Molecular Biology
  • Cell Physiology

Context:

  • Epithelial ion transport is a critical physiological process regulated by various membrane proteins.
  • Proton transporting ATPases, specifically V-type and P-type, play distinct roles in maintaining cellular and tissue homeostasis.

Purpose:

  • To provide a comprehensive summary of the properties, function, molecular structure, and distribution of V-type and P-type H(+)-ATPases.
  • To elucidate the specific roles of these ATPases in different physiological contexts, including organelle acidification and ion secretion/absorption.

Summary:

  • Vacuole-type H(+)-ATPases (V-ATPases) are responsible for acidifying intraorganellar spaces like lysosomes and synaptic vesicles, and contribute to proton secretion in kidney intercalated cells.
  • P-type H(+)-ATPases, specifically H+, K(+)-ATPase, are involved in gastric proton secretion and the secretion and potassium absorption in the distal colon.

Impact:

  • Understanding these proton pumps is essential for comprehending fundamental cellular processes and their dysregulation in disease.
  • This summary serves as a valuable resource for researchers investigating ion transport, cellular pH regulation, and related physiological and pathological conditions.

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