Related Experiment Video

Updated: Sep 16, 2026

Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation

Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation

Published on: January 28, 2021

Lipoproteins and diet in coronary heart disease; a five-year study

T P LYON, A YANKLEY, J W GOFMAN

California Medicine

|May 1, 1956

Insights

High lipoprotein atherogenic index indicates poor prognosis for coronary heart disease patients. A low-fat, low-cholesterol diet effectively lowers this index, reducing recurrence and death rates.

Area of Science:

Cardiology
Lipidology
Preventive Medicine

Background:

Coronary heart disease (CHD) is a leading cause of mortality.
Lipid disorders are key contributors to CHD.
The lipoprotein atherogenic index (LAI) is a marker for lipid abnormalities.

Purpose of the Study:

To confirm the association between elevated LAI and CHD.
To evaluate the prognostic value of LAI in myocardial infarction and angina pectoris.
To assess the impact of diet on LAI and patient outcomes.

Main Methods:

A five-year follow-up study involving 351 myocardial infarction patients and 119 angina pectoris patients.
Analysis of LAI values in relation to disease severity, prognosis, and mortality.
Comparison of LAI with serum cholesterol as a diagnostic marker.
Assessment of dietary adherence (low-fat, low-cholesterol diet) and its correlation with outcomes.

Main Results:

Elevated LAI was confirmed in patients with CHD.
High LAI was significantly associated with a worse prognosis in angina pectoris.
Deceased patients had significantly higher LAI values than survivors.
LAI proved superior to serum cholesterol in indicating lipid disorders in CHD.
A low-fat, low-cholesterol diet effectively maintained lowered LAI.
Non-adherence to the diet resulted in a fourfold increase in recurrence and death rates.

Conclusions:

The lipoprotein atherogenic index is a critical indicator of cardiovascular risk and prognosis.
Dietary modification, specifically a low-fat, low-cholesterol diet, plays a vital role in managing CHD through LAI reduction.
LAI measurement offers superior clinical utility compared to serum cholesterol for lipid disorder assessment in CHD.

Read full analysis

Abstract:

In a follow-up study for a five-year period of 351 patients with myocardial infarction and 119 patients with angina pectoris, the following observations were made:(a) The previously reported lipoprotein atherogenic index elevation in coronary heart disease was confirmed.(b) The prognosis in angina pectoris is strikingly and significantly worse when the lipoprotein atherogenic index is high.(c) Patients who died in the follow-up period showed significantly higher atherogenic index values than those who survived.(d) The lipoprotein atherogenic index measure is much superior to the serum cholesterol measurement as an indicator of the lipid disorder in coronary disease.(e) The low fat, low cholesterol diet is effective in maintaining chronically lowered lipoprotein atherogenic index values.(f) In patients who said they did not adhere to a low fat, low cholesterol diet, the recurrence and death rate was four times as high as in patients who stated they adhered to the diet.

Keywords:

BLOOD CORONARY DISEASE/therapy DIETS LIPOPROTEINS/in blood

More Related Videos

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Published on: October 12, 2017

Related Concept Videos

Coronary Artery Disease IV: Preventive Measures

Coronary Artery Disease IV: Preventive Measures

Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...

Blood Studies for Cardiovascular System III: Serum Lipid Profile

Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...

Lipid-Lowering Drugs: Statins and Miscellaneous Agents

Lipid-Lowering Drugs: Statins and Miscellaneous Agents

Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...

Atherosclerosis III: Management

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...

Lipid Digestion

Lipid Digestion

Lipids are large molecules that are generally not water-soluble. Since most of the digestive enzymes in the human body are water-based, there are specific steps the body must take to break down lipids and make them available for use.

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...