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Transient decrease in rat striatal D2 dopamine receptor mRNA level after acute haloperidol treatment.

M Sakata1, C Prasad

  • 1Laboratory of Neurosciences, Pennington Biomedical Research Center, Louisiana State University, Baton Rouge 70808.

Brain Research. Molecular Brain Research
|July 1, 1992
PubMed
Summary
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Acute haloperidol treatment transiently reduces D2 dopamine receptors in rat brains. This decrease in D2-receptor mRNA levels suggests reduced gene transcription, potentially mediated by D2-receptor blockade.

Area of Science:

  • Neuropharmacology
  • Molecular Neuroscience

Background:

  • Dopamine receptors play crucial roles in brain function.
  • Antipsychotic drugs like haloperidol interact with dopamine receptors.

Purpose of the Study:

  • To investigate the effect of acute haloperidol on D2 dopamine receptor levels.
  • To determine if decreased gene transcription contributes to the reduction in D2 receptors.

Main Methods:

  • Northern blot analysis was used to quantify D2-receptor mRNA levels in rat striatum.
  • The effects of haloperidol and sulpiride enantiomers were examined.

Main Results:

  • Haloperidol administration caused a dose- and time-dependent decrease in striatal D2-receptor mRNA.
  • The inhibitory effect on transcription was mimicked by S(-)-sulpiride but not R(+)-sulpiride, suggesting D2-receptor blockade mediation.

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Conclusions:

  • Acute haloperidol treatment leads to a transient reduction in D2 dopamine receptor mRNA.
  • This suggests that haloperidol-induced decrease in D2 receptors may involve the inhibition of their gene transcription via receptor blockade.