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Melatonin binding to the anteroventral and anterodorsal thalamic nuclei in the rat
O F Lindroos1, L M Leinonen, M L Laakso
1Department of Physiology, University of Helsinki, Finland.
Neuroscience Letters
|August 31, 1992
Abstract:
Pineal melatonin is a putative humoral coordinator of various circadian body rhythms. Rather few loci in the brain contain such a density of melatonin receptors that specific binding can be demonstrated by autoradiography. In this study we measured, using in vitro receptor autoradiography, displaceable binding of iodo-melatonin to the anteroventral and anterodorsal thalamic nuclei of Wistar rats (0.6-1.4 fmol/mg protein at 100 pM ligand concentration). These nuclei of the limbic system have direct connections with the retina and they participate in learning and memory functions.