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Biodistribution of intravenously injected [131I]Lipiodol in rats
1Department of Radiological Sciences, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Japan.
Radiation Medicine
|September 1, 1992
Abstract:
Tissue distribution studies of intravenously injected [131I]Lipiodol in rats were performed, and serial whole-body autoradiograms were obtained simultaneously for seven days. Most of the radiotracer was retained in the lungs. Lung uptake reached a maximum (42.44% ID/g) at 1 day, with an effective half-life of 3.0 days. The other organs showed markedly lower uptakes (less than 0.56% ID/g). The ratio between liver and lung reached a maximum (0.01) at 3 hr and then decreased with time, precluding adequate external imaging of the liver as compared with the lung.