[A case-control study on the relationship between smoking and genetic background and lung cancer]

A case-control study on the relationship between smoking and genetic background and lung cancer was carried out. The cases (probund) were death cases of lung cancer diagnosed between 1984 and 1986 in Quanshan County, and the controls were healthy people at the same period. Cases and controls were 1:1 in match with sex, age and residence. 196 pairs were so matched. The results were adjusted for smoking habit and family history of lung cancer using conditionally logistic regression model. There were significant differences shown in quantity of smoking (packet/year) (beta = 0.070 9) and age to start (years) (beta = -0.055 6) between cases and controls. There were also significant differences in history of lung cancer of first and second relatives (living together or not) between cases and controls. The positive interaction between smoking habit and genetic background of lung cancer was also found.