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Updated: Sep 11, 2026

A "Patient-Like" Orthotopic Syngeneic Mouse Model of Hepatocellular Carcinoma Metastasis
Published on: October 24, 2015
[Pathologic-ultrasonographic comparative study of carcinomatous lesions of experimental hepatic carcinoma in rats]
1Gastroenterology Research Section, Sun Yat-sen Memorial Hospital, Sun Yat-sen University of Medical Sciences, Guangzhon.
Abstract:
3'-Me-DAB was used to induce hepatic carcinoma in male Wistar rats. The pathologic-ultrasonographic comparative observation of forty-three carcinoma nodes of twenty-five rats showed that the echoic patterns of the nodes were determined not by the diameter, but by the pathologic types, the extent of hemorrhage or necrosis of lesions and the proliferative degree of the lattice fibers. The irregular vascularization, the dilatation of vessels and the tumoral cell fatty degeneration are related to the echoic patterns as well. This article also reports a preliminary study of the possibility that different structures and compositions of the carcinomatous nodes will produce different echoic levels.

