[Cholinergic suppression of the angiotensin I-converting reaction]

I. v. administration of carbachol or neostigmine produced a dose-dependent decrease in the angiotensin I pressor response and in conversion of angiotensin I to angiotensin II in anesthetized rats. Physostigmine produced the same effects in combination with propranolol. Administration of cholinomimetics with atropine leads to no such effect. The activation of the cholinergic system seems to inhibit a formation of angiotensin II.