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[The functional activity of the thrombocytes in chronic diseases of the large intestine]

U A Askarov, S N Navruzov, A K Khadzhiev

    Khirurgiia
    |April 1, 1992
    PubMed

    Insights

    Chronic large intestine diseases involve significant changes in blood platelet function, with recurrence linked to platelet activation. Treatments like Trental aim to correct these disorders, improving patient outcomes.

    Area of Science:

    • Gastroenterology
    • Hematology
    • Internal Medicine

    Background:

    • Chronic large intestine diseases, including colitis and amebiasis, present complex clinical challenges.
    • These conditions are associated with notable alterations in blood platelet activity and regulatory factors.

    Purpose of the Study:

    • To investigate the role of blood platelet functional activity in the pathogenesis of chronic large intestine diseases.
    • To evaluate the impact of treatment on platelet function and disease dynamics.
    • To explore the significance of biogenic amines and cyclic adenosine monophosphate (cAMP) in disease development.

    Main Methods:

    • Analysis of blood platelet functional activity and regulatory factors in patients with chronic large intestine diseases.
    • Monitoring disease dynamics before and after operative and nonoperative treatments.
    • Assessment of the effects of Trental and contrycal on platelet function and clinical symptoms.

    Main Results:

    • Marked changes in blood platelet functional activity were observed in patients with chronic large intestine diseases.
    • Disease recurrence correlated with increased blood platelet activation.
    • Treatment with Trental and contrycal led to improvements in some patients, suggesting a role in correcting platelet dysfunction.

    Conclusions:

    • Blood platelet functional activity and its regulation are crucial in the development and progression of chronic large intestine diseases.
    • Platelet activation is a key indicator of disease recurrence.
    • Biogenic amines and cAMP may represent universal mechanisms underlying these gastrointestinal disorders.

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