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[Cerebral metastasis disclosing primary bronchogenic cancers]
B Croisile1, V Trillet-Lenoir, J F Catajar
1Service de Neurologie, Hôpital Neurologique, Lyon.
Revue Neurologique
|January 1, 1992
Summary
Brain metastases are a common sign of lung cancer. Neurosurgery and radiotherapy significantly improve survival for lung cancer patients with brain metastases, especially when combined.
Area of Science:
- Oncology
- Neurology
- Thoracic Surgery
Context:
- Brain metastases are a frequent complication of lung cancer.
- Lung cancer patients often present with neurological symptoms due to brain involvement.
Purpose:
- To analyze the clinical presentation, treatment outcomes, and survival rates of lung cancer patients with brain metastases.
- To evaluate the efficacy of neurosurgery and radiotherapy in managing brain metastases from lung cancer.
Summary:
- This study reviewed 37 lung cancer patients with brain metastases, noting neurological symptoms, headache, and vomiting as common presentations.
- Small-cell lung carcinoma and non-small-cell lung carcinoma were observed, with overall median survival at 4.5 months.
- Neurosurgery, particularly combined with lung resection, and postoperative radiotherapy significantly improved median survival and reduced cerebral relapses.
Impact:
- Findings highlight the critical role of surgical and radiological interventions in improving outcomes for lung cancer patients with brain metastases.
- The study underscores the benefit of adjuvant radiotherapy following complete resection in preventing cerebral relapses.
- Chemotherapy showed efficacy in small-cell lung carcinoma but requires careful consideration due to toxicity when combined with radiotherapy.