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Related Experiment Videos

Recurrent herpetic keratitis during topical acyclovir application.

J M Soriano1, J Funk, P Janknecht

  • 1Universitäts-Augenklinik Freiburg, Germany.

European Journal of Ophthalmology
|July 1, 1992
PubMed
Summary
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A patient developed acyclovir-resistant herpetic keratitis during treatment. This condition, potentially linked to an underlying laryngeal carcinoma, highlights the importance of considering immune status in viral infections.

Area of Science:

  • Ophthalmology
  • Virology
  • Oncology

Background:

  • Herpetic keratitis is a common ocular infection caused by the herpes simplex virus.
  • Topical acyclovir is a standard treatment for herpetic keratitis.
  • Drug resistance can occur in viral infections, necessitating alternative therapeutic strategies.

Observation:

  • A 49-year-old patient presented with dendritic herpetic keratitis while undergoing topical acyclovir treatment.
  • Herpes simplex virus (HSV) cultures were positive, indicating active infection.
  • The patient was later diagnosed with laryngeal carcinoma.

Findings:

  • The herpetic keratitis resolved, and HSV cultures became negative after switching treatment from acyclovir to trifluridine and interferon.
  • This suggests the initial HSV infection was resistant to acyclovir.

Related Experiment Videos

  • Acyclovir-resistant HSV strains are often associated with compromised immune systems.

    • Implications:

    • The acyclovir-resistant herpetic keratitis may indicate an underlying immune deficiency, potentially linked to the laryngeal carcinoma.
    • This case underscores the need to investigate potential immune compromise in patients with recurrent or treatment-resistant herpetic infections.
    • Early detection of underlying conditions like cancer can be facilitated by observing unusual treatment responses in viral infections.