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Peripheral T-cell lymphoma involving the placenta.
P J Kurtin1, T A Gaffey, T M Habermann
1Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota 55905.
Cancer
|December 15, 1992
Summary
Maternal peripheral T-cell lymphoma (PTCL) rarely involves the placenta. Pregnancy may suppress PTCL, with rapid progression postpartum, suggesting unique immunologic interactions.
Area of Science:
- Oncology
- Immunology
- Obstetrics
Background:
- Maternal malignant lymphoma infrequently complicates pregnancy.
- Placental involvement by lymphoma is exceptionally rare.
Observation:
- A case of a 29-year-old pregnant woman with placental involvement by peripheral T-cell lymphoma (PTCL) is presented.
- Diagnosis was confirmed via morphologic, immunoperoxidase, and molecular genetic analyses.
Findings:
- The lymphoma was classified as pathologic Stage IVB.
- The child experienced no adverse effects, but the maternal neoplasm progressed rapidly postpartum.
Implications:
- Pregnancy-associated immunologic alterations may exert a lymphoma-suppressive effect.
- This case highlights a unique instance of placental PTCL, with no prior reports found.