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A simple synthesis of [11C]methyl triflate
1Department of Internal Medicine, University of Michigan Medical School, Ann Arbor 48109-0552.
International Journal of Radiation Applications and Instrumentation. Part A, Applied Radiation and Isotopes
|November 1, 1992
Summary
High yields of [11C]methyl triflate were achieved by passing [11C]methyl iodide over silver triflate on graphitized carbon at 200°C. This method offers an efficient route for producing this radiolabeling agent.
Area of Science:
- Radiochemistry
- Organic synthesis
- Nuclear medicine
Background:
- Efficient synthesis of radiolabeled compounds is crucial for Positron Emission Tomography (PET) imaging.
- Methylating agents are widely used in radiolabeling, but their synthesis can be challenging.
Purpose of the Study:
- To develop a high-yield method for the synthesis of [11C]methyl triflate.
- To investigate the use of silver triflate supported on graphitized carbon for this reaction.
Main Methods:
- [11C]methyl iodide was generated and passed through a heated column (200°C).
- The column contained graphitized carbon impregnated with 50% silver triflate by weight.
- The product, [11C]methyl triflate, was collected and analyzed.
Main Results:
- [11C]methyl triflate was formed in high yield.
- The reaction was efficient under the tested conditions.
Conclusions:
- The described method provides an effective route for the preparation of [11C]methyl triflate.
- This approach is suitable for radiopharmaceutical development and PET imaging applications.
