Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Native cytokine antagonists.

J W Larrick, S C Wright

    Bailliere'S Clinical Haematology
    |July 1, 1992
    PubMed
    Summary
    This summary is machine-generated.

    Cytokine regulation is complex. This review details how endogenous antagonists, soluble receptors, and other cytokines inhibit cytokine actions, offering insights into immune system homeostasis.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Magneto-Optical Trapping of Aluminum Monofluoride.

    Physical review letters·2026
    Same author

    The chemistry of AlF and CaF production in buffer gas sources.

    The Journal of chemical physics·2022
    Same author

    Hyperfine-resolved optical spectroscopy of the A<sup>2</sup>Π ← X<sup>2</sup>Σ<sup>+</sup> transition in MgF.

    The Journal of chemical physics·2022
    Same author

    Contrasting effects of Na+, K+-ATPase activation on seizure activity in acute versus chronic models.

    Neuroscience·2015
    Same author

    Mortality and drug exposure in a 5-year cohort of patients with chronic liver disease.

    Swiss medical weekly·2009
    Same author

    Treatment of oral thrush in HIV/AIDS patients with lemon juice and lemon grass (Cymbopogon citratus) and gentian violet.

    Phytomedicine : international journal of phytotherapy and phytopharmacology·2008
    Same journal

    Current status of stem cell therapy and prospects for gene therapy for the disorders of globin synthesis.

    Bailliere's clinical haematology·2000
    Same journal

    Pharmacological therapy.

    Bailliere's clinical haematology·2000
    Same journal

    Prenatal diagnosis and screening of the haemoglobinopathies.

    Bailliere's clinical haematology·2000
    Same journal

    Sickle cell disease: clinical management.

    Bailliere's clinical haematology·2000
    Same journal

    Pathophysiology of sickle cell disease.

    Bailliere's clinical haematology·2000
    Same journal

    Thalassaemia: clinical management.

    Bailliere's clinical haematology·2000
    See all related articles

    Area of Science:

    • Immunology
    • Molecular Biology

    Background:

    • Cytokines are crucial for cell and tissue homeostasis, acting via autocrine and paracrine pathways.
    • Mechanisms regulating cytokine activity are not fully understood, necessitating research into inhibitory processes.

    Purpose of the Study:

    • To summarize current knowledge on cytokine antagonism and inhibition.
    • To highlight emerging concepts in cytokine regulation.

    Main Methods:

    • Review of existing literature on cytokine inhibition.
    • Analysis of endogenous antagonists, soluble receptors, and inhibitory cytokines.

    Main Results:

    • Identified endogenous receptor antagonists for IL-1 alpha and IL-1 beta (IL-1 receptor antagonist).
    • Noted inhibition of various cytokines (TNF, IFN-gamma, IL-2, IL-4) by soluble receptors.

    Related Experiment Videos

  • Highlighted cytokines (IL-10, TGF-beta, MDF) that inhibit other cytokines, suggesting pleiotropic effects.

    • Conclusions:

    • Cytokine inhibition involves diverse mechanisms including receptor antagonists, soluble receptors, and cross-regulatory cytokine networks.
    • Further research is needed to elucidate the complex interplay of these inhibitory mechanisms in vivo.