[Peripheral neuropathy associated with Castleman's lymphoma].

Area of Science:

• Oncology
• Neurology
• Pathology

Background:

• Castleman's lymphoma is a rare disorder with distinct histopathological variants.
• It can be multifocal or unifocal, often presenting in the thorax.
• The plasma cellular variant is linked to systemic symptoms, including neuropathy.

Observation:

• This report details a rare case of unifocal, plasma cellular Castleman's lymphoma in the mediastinum.
• The patient was initially asymptomatic, later developing chronic motor-predominant polyneuropathy.
• This presentation highlights an unusual manifestation of the disease.

Findings:

• The case illustrates a rare unifocal, plasma cellular Castleman's lymphoma.
• Neurological symptoms, specifically chronic isolated polyneuropathy, emerged as the dominant clinical feature.
• The study reviews key clinico-histological features and proposes pathogenic hypotheses for associated neuropathy.

Implications:

• This case expands the understanding of Castleman's lymphoma presentations.
• It underscores the importance of considering Castleman's lymphoma in unexplained polyneuropathy.
• Further research into the pathogenesis of Castleman's lymphoma-associated neuropathy is warranted.