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[Obesity: danger for the hepatocytes?].
1Service de Médecine Interne, Hôpital de Jolimont, Haine-St-Paul.
Acta Clinica Belgica
|January 1, 1992
Summary
Obesity can lead to non-alcoholic steatohepatitis (NASH), a liver condition resembling alcoholic hepatitis. This review covers NASH in obese individuals, focusing on its characteristics, treatment, and clinical management.
Area of Science:
- Hepatology
- Endocrinology
- Gastroenterology
Context:
- Obesity is a growing global health concern.
- Non-alcoholic steatohepatitis (NASH) is an increasingly recognized liver condition.
- NASH shares histological similarities with alcoholic hepatitis.
Purpose:
- To review the literature on histological liver lesions in obese patients.
- To describe the epidemiology, clinical presentation, and biological features of NASH.
- To discuss the evolution, treatment, and pathophysiology of NASH.
Summary:
- Non-alcoholic steatohepatitis (NASH) is a distinct liver lesion associated with obesity, diabetes, and hyperlipidemia, primarily affecting middle-aged women.
- Histological findings, clinical characteristics, and biological markers of NASH are reviewed.
- The review covers the natural history, therapeutic strategies, and underlying physiopathology of NASH, offering guidance for clinical management.
Impact:
- Provides a comprehensive overview of NASH for clinicians.
- Highlights the importance of recognizing and managing NASH in obese patients.
- Contributes to understanding the link between metabolic disorders and liver disease.