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[Ca2+]i effects of bradykinin B2 receptor activation in PC12 cells
F Grohovaz1, D Zacchetti, P D' Andrea
1B. Ceccarelli Ctr, Dept Pharmacology, University of Milano, Italy.
Agents and Actions. Supplements
|January 1, 1992
Abstract:
In PC12 cells, activation of B2 receptors by bradykinin promotes an elevation of cytosolic Ca2+ by two mechanisms: IP3 mediated release of Ca2+ from intracellular stores and stimulation of multiple Ca2+ influx pathways. Since these events can have different kinetics and spatial localizations they can induce diversified effects in different cell areas.