Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Bone resorption by cells isolated from rheumatoid synovium.

J S Chang1, J M Quinn, A Demaziere

  • 1Nuffield Department of Orthopaedic Surgery, Nuffield Orthopaedic Centre, Oxford, United Kingdom.

Annals of the Rheumatic Diseases
|November 1, 1992
PubMed
Summary

Macrophages in rheumatoid arthritis (RA) synovium cause bone surface roughening, a distinct form of osteolysis. This mechanism, unlike osteoclast activity, is unaffected by common bone resorption factors, highlighting a novel pathway in RA joint erosion.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Fasciola gigantica: Ultrastructure and cytochemistry of tegumental secretory activity and extracellular vesicle formation in juvenile flukes migrating in mouse liver.

Veterinary parasitology·2026
Same author

Fasciola gigantica: Ultrastructural localisation of neoblast recruitment in somatic tissues during growth and development in the hepatic parenchyma of experimentally infected mice.

Veterinary parasitology·2024
Same author

The association between UGT1A1 polymorphisms and treatment toxicities of liposomal irinotecan.

ESMO open·2022
Same author

Postoperative Pneumonia and Aspiration Pneumonia Following Elderly Hip Fractures.

The journal of nutrition, health & aging·2022
Same author

Artificial intelligence and surgical innovation: lower limb arthroplasty.

British journal of hospital medicine (London, England : 2005)·2020
Same author

Atypical subtrochanteric fractures in Korean hip fracture study.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2017

Area of Science:

  • Rheumatology
  • Cell Biology
  • Orthopedics

Background:

  • Osteolysis in rheumatoid arthritis (RA) erosions is a key pathological feature.
  • The specific cellular mechanisms driving bone resorption in RA remain incompletely understood.

Purpose of the Study:

  • To investigate the cellular mechanisms responsible for osteolysis in rheumatoid arthritis (RA).
  • To characterize the bone resorption capabilities of synovial cells from RA patients.

Main Methods:

  • Synovial cells were isolated from patients with rheumatoid arthritis (RA) and osteoarthritis.
  • Bone resorption was assessed using a scanning electron microscope bone resorption assay.
  • Macrophage activity and response to systemic and local factors were evaluated.

Related Experiment Videos

Main Results:

  • Macrophages were the predominant cell type isolated from RA synovium.
  • RA macrophages induced significant bone surface roughening but not distinct resorption pits.
  • This macrophage-mediated bone resorption was unresponsive to systemic factors (calcitonin, PTH, 1,25-dihydroxyvitamin D3) and local factors (IL-1, PGE2).

Conclusions:

  • Macrophage-mediated bone resorption in RA differs qualitatively and quantitatively from osteoclast activity.
  • This distinct macrophage function likely contributes significantly to the marginal erosions observed in rheumatoid arthritis.
  • Understanding this mechanism may offer new therapeutic targets for RA joint destruction.