Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Synaptic plasticity in rat hippocampus associated with learning.

J Van Reempts1, M Dikova, L Werbrouck

  • 1Department of Morphology, Janssen Research Foundation, Beerse, Belgium.

Behavioural Brain Research
|November 15, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Response to exercise and mechanical efficiency in non-ischaemic stunning, induced by short-term rapid pacing in dogs: a role for calcium?

Acta physiologica (Oxford, England)·2015
Same author

Ultrastructural calcium distribution and myocardial calcium content in human idiopathic dilated cardiomyopathy.

Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology·2015
Same author

Chronic ischemic viable myocardium in man: Aspects of dedifferentiation.

Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology·2015
Same author

Contact sites between the inner and outer mitochondrial membranes in stunned versus hibernating myocardium.

Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology·2015
Same author

Chronic hibernating myocardium in sheep can occur without degenerating events and is reversed after revascularization.

Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology·2014
Same author

The effect of antifungal treatment on the vaginal flora of women with vulvo-vaginal yeast infection with or without bacterial vaginosis.

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology·2010
Same journal

Understanding vulnerability through variability: a longitudinal twin study linking sex differences in neurodiversity, neurodevelopment and X-linked genetic mechanisms.

Behavioural brain research·2026
Same journal

Hippocampal plasticity predicts behavioral lateralization and stress resilience in laying hen chicks.

Behavioural brain research·2026
Same journal

Effects of retatrutide on learning and memory in streptozotocin-induced male diabetic rats.

Behavioural brain research·2026
Same journal

Bacopa-Enriched Formulation Enhances Memory and Synaptic Plasticity in a Rat Model of Vascular Dementia.

Behavioural brain research·2026
Same journal

Prior exposure to methylphenidate attenuates ethanol-induced conditioned place preference in zebrafish.

Behavioural brain research·2026
Same journal

Plasma nectin-4 levels are associated with changes in executive function in patients with methamphetamine use disorder undergoing treatment.

Behavioural brain research·2026
See all related articles

Active avoidance training in rats induced significant changes in hippocampal dendritic spine morphology. Synaptic remodeling and increased postsynaptic density length were observed, indicating adaptive neural plasticity.

Area of Science:

  • Neuroscience
  • Cell Biology
  • Behavioral Science

Background:

  • Synaptic plasticity is crucial for learning and memory.
  • Understanding structural changes in neurons during learning is essential.

Purpose of the Study:

  • To investigate the effects of active avoidance training on hippocampal dendritic spine morphology in rats.
  • To analyze synaptic remodeling and postsynaptic density changes associated with learning.

Main Methods:

  • Rats underwent three daily sessions of one-way active avoidance training.
  • Hippocampal supragranular molecular layer dendritic spines were analyzed.
  • Morphological changes, including synapse perforation and postsynaptic density length, were quantified.
  • Comparisons were made between trained, untrained, and sham-shocked groups.

Related Experiment Videos

Main Results:

  • Active avoidance training significantly improved performance across sessions.
  • A notable increase in perforated concave synapses was observed in trained rats.
  • Postsynaptic density length increased significantly in both perforated and non-perforated synapses.
  • Changes were more pronounced compared to sham-shocked and untrained controls.

Conclusions:

  • One-way active avoidance training induces significant synaptic remodeling in the hippocampus.
  • These structural modifications, including increased synapse perforation and postsynaptic density length, reflect adaptive neural plasticity.
  • The findings support the role of synaptic turnover in learning and memory consolidation.