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Malignant placental site trophoblastic tumor associated with placental abruption, fetal distress, and elevated CA-125

M P Hopkins1, C W Drescher, A McQuillan

  • 1Department of Obstetrics & Gynecology, University of Michigan Medical Center, Ann Arbor.

Gynecologic Oncology
|November 1, 1992
PubMed

The second pregnancy of 27-year-old woman, gravida 2, para 2 was complicated by a low alpha-fetoprotein and symptoms of chronic placental abruption. She delivered by cesarean section at 35 weeks for fetal distress at which time a biopsy of the uterus revealed a placental site trophoblastic tumor (PSTT). She rapidly developed intraabdominal spread of the neoplasm which did not respond to chemotherapy and she died 10 weeks later. Her CA-125 was elevated to 5360 mu/ml and this decreased after hysterectomy. This patient is reported to highlight a very malignant course of PSTT that was associated with a live-born male infant.

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