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Published on: April 25, 2014
Prognosis in hypertensives with acute myocardial infarction
J Herlitz1, B W Karlson, A Richter
1Department of Medicine I, Sahlgrenska Hospital, Gothenburg, Sweden.
Insights
Patients with a history of hypertension hospitalized for acute myocardial infarction face a poorer prognosis. These individuals have higher mortality and reinfarction rates within one year post-discharge compared to normotensive patients.
Area of Science:
- Cardiology
- Hypertension Research
- Acute Myocardial Infarction
Background:
- Hypertension is frequently observed in patients with ischemic heart disease.
- Understanding the impact of prior hypertension on acute myocardial infarction (AMI) prognosis is crucial for patient management.
Purpose of the Study:
- To investigate the influence of a previous history of hypertension on the prognosis of patients hospitalized with acute myocardial infarction.
Main Methods:
- A prospective study followed 917 patients hospitalized for AMI over 1 year.
- Data collected included patient history, in-hospital outcomes, and post-discharge mortality and morbidity.
Main Results:
- A history of hypertension was reported in 324 AMI patients, who also had higher rates of prior myocardial infarction, angina, heart failure, and diabetes.
- While in-hospital mortality was similar, 1-year total mortality was significantly higher in hypertensive patients (35%) versus normotensive patients (25%).
- Hypertension independently predicted death and reinfarction, which occurred twice as frequently in hypertensive patients.
Conclusions:
- A history of hypertension is a significant indicator of poor prognosis in acute myocardial infarction patients.
- Hypertensive patients face a one-third risk of death and a one-quarter risk of reinfarction within the first year following AMI.
Objectives:
A previous history of hypertension is overrepresented among patients with ischaemic heart disease. The present study aims at describing the influence of a previous history of hypertension upon the prognosis among patients hospitalized due to acute myocardial infarction.
Design:
Patients were followed for 1 year. Mortality and morbidity are described during hospitalization and after discharge from hospital.
Setting:
Sahlgrenska Hospital, serving half of the area of Gothenburg in Sweden.
Patients:
All patients admitted to Sahlgrenska Hospital during 21 months due to acute myocardial infarction regardless of age and whether they were admitted to the coronary care unit.
Results:
Among all patients with confirmed acute myocardial infarction (n = 917) a previous history of hypertension was reported in 324 patients. Hypertensives more frequently had a previous history of acute myocardial infarction, angina pectoris, congestive heart failure and diabetes mellitus. Their mortality during hospitalization was similar to that in normotensives. However, the total mortality during 1 year of follow-up was 35% in hypertensives and 25% for normotensives (P < 0.01), and a previous history of hypertension was an independent risk indicator for death after discharge from hospital. Place and mode of death appeared similar in normotensives and hypertensives. Reinfarction was twice as common in hypertensives as in normotensives, and a previous history of hypertension was an independent risk indicator for reinfarction.
Conclusions:
Among patients with acute myocardial infarction a previous history of hypertension indicates a poor prognosis, one-third of patients dying and one-quarter developing reinfarction during the first year after onset of acute myocardial infarction.
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